TCTP protein degradation by targeting mTORC1 and signaling through S6K, Akt, and Plk1 sensitizes lung cancer cells to DNA-damaging drugs
Abstract Translationally controlled tumor protein (TCTP) is expressed in many tissues, particularly General Aviation in human tumors.It plays a role in malignant transformation, apoptosis prevention, and DNA damage repair.The signaling mechanisms underlying TCTP regulation in cancer are only partially understood.Here, we investigated the role of mT