TCTP PROTEIN DEGRADATION BY TARGETING MTORC1 AND SIGNALING THROUGH S6K, AKT, AND PLK1 SENSITIZES LUNG CANCER CELLS TO DNA-DAMAGING DRUGS

TCTP protein degradation by targeting mTORC1 and signaling through S6K, Akt, and Plk1 sensitizes lung cancer cells to DNA-damaging drugs

Abstract Translationally controlled tumor protein (TCTP) is expressed in many tissues, particularly General Aviation in human tumors.It plays a role in malignant transformation, apoptosis prevention, and DNA damage repair.The signaling mechanisms underlying TCTP regulation in cancer are only partially understood.Here, we investigated the role of mT

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Violence Against Native American Women in the United States

In response to the topic of Global Justice and Human Rights: Country Case Studies, I will helmets discuss the origin and continuation of violence against Native American women in the United States.In a report named Maze of Injustice: The Failure to Protect Indigenous Women from Violence by Amnesty International, the organization deemed the current

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Genome-Wide Expression and Physiological Profiling of Pearl Millet Genotype Reveal the Biological Pathways and Various Gene Clusters Underlying Salt Resistance

Pearl millet (Pennisetum glaucum L.) is a vital staple food and an important cereal crop used as food, feed, and forage.It can withstand heat and drought due to the presence of some unique genes; however, the mechanism of salt stress has been missing in pearl millet until now.Therefore, we conducted a comparative transcriptome profiling to reveal t

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Germination and growth of purple passion fruit seedlings under pre-germination treatments and mycorrhizal inoculation

The cultivation of purple passion fruit plants has increased in Colombia, as a direct result of its well-accepted consumption.Therefore, there is a need for technological solutions aimed at the sustainable growth of Parts its fruit, such as improving seed germination and decreasing phosphorus (P) deficiencies, given its low availability in tropical

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